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Shi, J.* ; Shiraishi, K.* ; Choi, J.* ; Matsuo, K.* ; Chen, T.Y.* ; Dai, J.* ; Hung, R.J.* ; Chen, K.* ; Shu, X.O.* ; Kim, Y.T.* ; Landi, M.T.* ; Lin, D.* ; Zheng, W.* ; Yin, Z.* ; Zhou, B.* ; Song, B.* ; Wang, J.* ; Seow, W.J.* ; Song, L.* ; Chang, I.S.* ; Hu, W.* ; Chien, L.H.* ; Cai, Q.* ; Hong, Y.C.* ; Kim, H.N.* ; Wu, Y.L.* ; Wong, M.P.* ; Richardson, B.D.* ; Funderburk, K.M.* ; Li, S.* ; Zhang, T.* ; Breeze, C.* ; Wang, Z. [extern]* ; Blechter, B.* ; Bassig, B.A.* ; Kim, J.H.* ; Albanes, D.* ; Wong, J.Y.Y.* ; Shin, M.H.* ; Chung, L.P.* ; Yang, Y.* ; An, S.J.* ; Zheng, H.* ; Yatabe, Y.* ; Zhang, X.C.* ; Kim, Y.C.* ; Caporaso, N.E.* ; Chang, J.* ; Ho, J.C.M.* ; Kubo, M.* ; Daigo, Y.* ; Song, M.* ; Momozawa, Y.* ; Kamatani, Y.* ; Kobayashi, M.* ; Okubo, K.* ; Honda, T.* ; Hosgood, D.H.* ; Kunitoh, H.* ; Patel, H.* ; Watanabe, S.i.* ; Miyagi, Y.* ; Nakayama, H.* ; Matsumoto, S.* ; Horinouchi, H.* ; Tsuboi, M.* ; Hamamoto, R.* ; Goto, K.* ; Ohe, Y.* ; Takahashi, A.* ; Goto, A.* ; Minamiya, Y.* ; Hara, M.* ; Nishida, Y.* ; Takeuchi, K.* ; Wakai, K.* ; Matsuda, K.* ; Murakami, Y.* ; Shimizu, K.* ; Suzuki, H.* ; Saito, M.* ; Ohtaki, Y.* ; Tanaka, K.* ; Wu, T.* ; Wei, F.* ; Dai, H.* ; Machiela, M.J.* ; Su, J.* ; Kim, Y.H.* ; Oh, I.J.* ; Lee, V.H.F.* ; Chang, G.C.* ; Tsai, Y.H.* ; Chen, K.Y.* ; Huang, M.S.* ; Su, W.C.* ; Chen, Y.M.* ; Seow, A.* ; Park, J.Y.* ; Kweon, S.S.* ; Chen, K.C.* ; Gao, Y.T.* ; Qian, B.* ; Wu, C.* ; Lu, D.* ; Liu, J.* ; Schwartz, A.G.* ; Houlston, R.* ; Spitz, M.R.* ; Gorlov, I.P.* ; Wu, X.* ; Yang, P.* ; Lam, S.* ; Tardón, A.* ; Chen, C.* ; Bojesen, S.E.* ; Johansson, M.* ; Risch, A.* ; Bickeböller, H.* ; Ji, B.T.* ; Wichmann, H.-E. ; Christiani, D.C.* ; Rennert, G.* ; Arnold, S.* ; Brennan, P.* ; Mckay, J.* ; Field, J.K.* ; Shete, S.S.* ; Le Marchand, L.* ; Liu, G.* ; Andrew, A.* ; Kiemeney, L.A.* ; Zienolddiny-Narui, S.* ; Grankvist, K.* ; Cox, A.* ; Taylor, F.* ; Yuan, J.M.* ; Lazarus, P.* ; Schabath, M.B.* ; Aldrich, M.C.* ; Jeon, H.S.* ; Jiang, S.S.* ; Sung, J.S.* ; Chen, C.H.* ; Hsiao, C.F.* ; Jung, Y.J.* ; Guo, H.* ; Hu, Z.* ; Burdett, L.* ; Yeager, M.* ; Hutchinson, A.* ; Hicks, B.* ; Zhu, B.* ; Berndt, S.I.* ; Wu, W.* ; Li, Y.* ; Choi, J.E.* ; Park, K.H.* ; Sung, S.W.* ; Liu, L.* ; Kang, C.H.* ; Wang, W.C.* ; Xu, J.* ; Guan, P.* ; Tan, W.* ; Yu, C.J.* ; Yang, G.* ; Sihoe, A.D.L.* ; Chen, Y.* ; Choi, Y.Y.* ; Kim, J.S.* ; Yoon, H.I.* ; Park, I.K.* ; Xu, P.* ; He, Q.* ; Wang, C.L.* ; Hung, H.H.* ; Vermeulen, R.C.H.* ; Cheng, I.* ; Wu, J.* ; Lim, W.Y.* ; Tsai, F.Y.* ; Chan, J.K.C.* ; Li, J.* ; Chen, H.* ; Lin, H.C.* ; Jin, L.* ; Sawada, N.* ; Yamaji, T.* ; Wyatt, K.* ; Li, S.A.* ; Ma, H.* ; Zhu, M.* ; Wang, Z.* ; Cheng, S.* ; Li, X.* ; Ren, Y.* ; Chao, A.* ; Iwasaki, M.* ; Zhu, J.* ; Jiang, G.* ; Fei, K.* ; Wu, G.* ; Chen, C.Y.* ; Chen, C.J.* ; Yang, P.C.* ; Yu, J.* ; Stevens, V.L.* ; Fraumeni, J.F.* ; Chatterjee, N.* ; Gorlova, O.Y.* ; Hsiung, C.A.* ; Amos, C.I.* ; Shen, H.* ; Chanock, S.J.* ; Rothman, N.* ; Kohno, T.* ; Lan, Q.*

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Nat. Commun. 14:3043 (2023)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cancer Susceptibility Loci; Surfactant Protein-b; Never-smoking Women; Telomere Length; Genetic-variants; Risk-factors; Identifies 2; Metaanalysis; Multiple; Heritability
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 3043 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology I (EPI)
Förderungen
Lusi Wong Fund of the Princess Margaret Cancer Foundation
Alan Brown Chair
Mayo Clinic Foundation Research Funds
National Health Research Institutes
CPRIT grant
CIHR FDN
Canadian Institute for Health Research (CIHR) Canada Research Chair
NIH
Ministry of Health and Welfare
Tianjin Science and Technology Committee Foundation
National Natural Science of China
National Research Foundation of Korea (NRF) grant - Korea government (MSIT)
NIH Genes, Environment and Health Initiative (GEI)
American Cancer Society
National Cancer Institute, National Institutes of Health
U.S. Public Health Service contracts from the NCI
Intramural Research Program of the National Institutes of Health, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics
General Research Fund of Research Grant Council, Hong Kong
NCI
Ministry of Education, Science, Sports, Culture and-Technology of Japan
Ministry of Health, Labor, and Welfare
NCI Intramural Research Program contract
National Cancer Institute intramural research program
National Institutes of Health
U.S. National Institutes of Health, National Cancer Institute
National Science Council, Taiwan
Agency for Science, Technology and Research (A*STAR) of Singapore
National Medical Research Council Singapore grant
National Key Basic Research Program Grant
Priority Academic Program Development of Jiangsu Higher Education Institution
China National High-Tech Research and Development Program Grant
Scientific and Technological Support Plans from Jiangsu Province
National Basic Research Program
National Science Foundation of China
China National High-Tech Research and Development Program
National S&T Major Special Project
Ministry of Science and Technology
Ministry of Health
National Foundation for Cancer Research (US)
Tianjin Cancer Institute and Hospital
Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT), China
Natural Science Foundation of Guangdong Province
Chinese Lung Cancer Research Foundation
Guangzhou Science and Information Technology Bureau
Foundation of Guangdong Science and Technology Department
China Medical Board
Liaoning Provincial Department of Education
National Nature Science Foundation of China
National Key Basic Research and Development Program
National R&D Program for Cancer Control, Ministry of Health &Welfare, Republic of Korea
US National Institutes of Health/National Cancer Institute
US National Institute of Health Grant
Agency for Science, Technology and Research (A*STAR), Singapore
Sookmyung Women's University Research Grants, Korea
National Research Foundation of Korea (NRF) grant - Korea government (MSIP)
State Key Program of National Natural Science of China
National Key Scientific and Technological Project
Jinan Science Research Project Foundation
Bioinformatics Core Facility for Translational Medicine and Biotechnology Development
National Research Program for Biopharmaceuticals in Taiwan
National Research Program on Genomic Medicine in Taiwan
Ministry of Health, Labour and Welfare of Japan
National Cancer Center Research and Development Fund
Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government
Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and Development
Ministry of Science and Technology, Taiwan
Special Fund for Research in the Public Interest from the National Health and Family Planning Commission of PRC
Guangdong Provincial Key Laboratory of Lung Cancer Translational Medicine
National Natural Science Foundation of China
MOE 111 Project
National Science & Technology Pillar Program
Program for Changjiang Scholars and Innovative Research Team in University in China
National Project for Personalized Genomic Medicine, Ministry for Health & Welfare, Republic of Korea
National Research Foundation of Korea (NRF) grant - Korea government (MEST)
Health and Labor Sciences Research Grants for Research on Applying Health Technology from the Ministry of Health, Labor and Welfare of Japan
Ministry Health, Labor and Welfare of Japan
Ministry of Education, Science, Sports, Culture and Technology of Japan