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Smith, J.A.B.* ; Murach, K.A.* ; Dyar, K.A. ; Zierath, J.R.*

Exercise metabolism and adaptation in skeletal muscle.

Nat. Rev. Mol. Cell Biol. 24, 607-632 (2023)
DOI PMC
Viewing metabolism through the lens of exercise biology has proven an accessible and practical strategy to gain new insights into local and systemic metabolic regulation. Recent methodological developments have advanced understanding of the central role of skeletal muscle in many exercise-associated health benefits and have uncovered the molecular underpinnings driving adaptive responses to training regimens. In this Review, we provide a contemporary view of the metabolic flexibility and functional plasticity of skeletal muscle in response to exercise. First, we provide background on the macrostructure and ultrastructure of skeletal muscle fibres, highlighting the current understanding of sarcomeric networks and mitochondrial subpopulations. Next, we discuss acute exercise skeletal muscle metabolism and the signalling, transcriptional and epigenetic regulation of adaptations to exercise training. We address knowledge gaps throughout and propose future directions for the field. This Review contextualizes recent research of skeletal muscle exercise metabolism, framing further advances and translation into practice.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Activated Protein-kinase; Hormone-sensitive Lipase; Respiratory-chain Supercomplexes; Fatty-acid Transport; Glucose-uptake; Fiber-type; Dynamic Exercise; Induced Increase; Creatine-kinase; Cardiorespiratory Fitness
ISSN (print) / ISBN 1471-0072
e-ISSN 1471-0080
Zeitschrift Nature Reviews - Molecular Cell Biology
Quellenangaben Band: 24, Heft: 9, Seiten: 607-632 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen
Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen
Swedish Research Council for Sport Science
Swedish Research Council (Vetenskapsradet)
Deutsches Zentrum fur Diabetesforschung
National Institutes of Health