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Shintani, M.* ; Vestergaard, G.* ; Milaković, M.* ; Kublik, S. ; Smalla, K.* ; Schloter, M. ; Udiković-Kolić, N.*

Integrons, transposons and IS elements promote diversification of multidrug resistance plasmids and adaptation of their hosts to antibiotic pollutants from pharmaceutical companies.

Environ. Microbiol. 25, 3035-3051 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Plasmids are important vehicles for the dissemination of antibiotic resistance genes (ARGs) among bacteria by conjugation. Here, we determined the complete nucleotide sequences of nine different plasmids previously obtained by exogenous plasmid isolation from river and creek sediments and wastewater from a pharmaceutical company. We identified six IncP/P-1ε plasmids and single members of IncL, IncN and IncFII-like plasmids. Genetic structures of the accessory regions of the IncP/P-1ε plasmids obtained implied that multiple insertions and deletions had occurred, mediated by different transposons and Class 1 integrons with various ARGs. Our study provides compelling evidence that Class 1 integrons, Tn402-like transposons, Tn3-like transposons and/or IS26 played important roles in the acquisition of ARGs across all investigated plasmids. Our plasmid sequencing data provide new insights into how these mobile genetic elements could mediate the acquisition and spread of ARGs in environmental bacteria.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Water Treatment-plant; Range Plasmids; Nucleotide-sequence; Provides Evidence; Incp-1 Plasmids; Soil; Genes; Environment; Diverse; River
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1462-2912
e-ISSN 1462-2920
Zeitschrift Environmental Microbiology
Quellenangaben Band: 25, Heft: 12, Seiten: 3035-3051 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Comparative Microbiome Analysis (COMI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504700-001
Förderungen Research Institute of Green Science and Technology Fund for Research Project Support, Shizuoka University
Consortium for the Exploration of Microbial Functions Ohsumi Frontier Science Foundation
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
Hrvatska Zaklada za Znanost
Short Term Scientific Mission Grant from the COST (European Cooperation in Science and Technology) Action ES1403 NEREUS
Asahi Glass Foundation
DOI 10.1111/1462-2920.16481
WOS ID 001059708900001
Scopus ID 85169476885
PubMed ID 37655671
Erfassungsdatum 2023-10-18
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