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Ferroptosis in health and disease.

Redox Biol. 75:103211 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells' susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with - or caused by - ferroptosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Cancer ; Cell Death ; Iron ; Ischemia/reperfusion ; Lipid Peroxidation ; Neurodegeneration; Glutathione-peroxidase 4; Oxidative Glutamate Toxicity; Polyunsaturated Fatty-acids; Cell-death Recommendations; Oxygen Species Production; Measuring Reactive Oxygen; Persister Cancer-cells; Gtp-cyclohydrolase-i; Transfer-rna Gene; Lipid-peroxidation
ISSN (print) / ISBN 2213-2317
e-ISSN 2213-2317
Zeitschrift Redox Biology
Quellenangaben Band: 75, Heft: , Seiten: , Artikelnummer: 103211 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Metabolism and Cell Death (MCD)
Institute of Diabetes and Cancer (IDC)
Institute of Stem Cell Research (ISF)
Institute of Lung Biology (LHI)
Research Unit Analytical BioGeoChemistry (BGC)
Institute for Allergy Research (IAF)
Förderungen DFG (German Research Foundation)
NIH
NSERC
DFG projects Germany's Excellence Strategy
German Federal Ministry of Education and Research (BMBF) FERROPATH
Fonds der chemischen Industrie, Physician Scientist Program of the Medical Faculty Heidelberg
SMWK
German Cancer Research Center (DKFZ)
Helmholtz Center, Consortium of excellence at University of Antwerp INFLA-MED
EU
ERC
Industrial Research Fund
BOF-IMPULS from University of Antwerp, Foundation against cancer
GIGG consortia
VIB
American Cancer Society
Bakar Fellows Spark Award
Ministry of Science & Technology of the State of Israel
Israel Science Foundation
JST CREST
JSPS Kakenhi
National Research Foundation of Korea
Seoul National University
CRIG
Special Research Fund UGent
Charcot Foundation
VLIRUOS
Research Foundation Flanders
EOS CD-INFLADIS
National Natural Science Foundation of China