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Open Access Green: Postprint online verfügbar 07/2025
möglich sobald bei der ZB eingereicht worden ist.
Epigenomic differences between osteoarthritis grades in primary cartilage.
Osteoarthr. Cartil. 32, 1126-1133 (2024)
DOI
PMC
OBJECTIVE: Osteoarthritis is a common and complex joint disorder that shows higher prevalence and greater disease severity in women. Here, we investigate genome-wide methylation profiles of primary chondrocytes from osteoarthritis patients. DESIGN: We compare genome-wide methylation profiles of macroscopically intact (low-grade) and degraded (high-grade) osteoarthritis cartilage samples matched from osteoarthritis patients undergoing knee replacement surgery. We perform an epigenome-wide association study (EWAS) for cartilage degeneration across 170 patients and separately in 96 women and 74 men. RESULTS: We reveal widespread epigenetic differences with enrichments of nervous system and apoptosis-related processes. We further identify substantial similarities between sexes, but also sex-specific markers and pathways. CONCLUSIONS: Together, we provide the largest genome-wide methylation profiles of primary cartilage to date with enhanced and sex-specific insights into epigenetic processes underlying osteoarthritis progression.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Dna Methylation ; Ewas ; Osteoarthritis ; Cartilage ; Chondrocytes ; Sex Specificity; Sex-differences; Knee; Identification; Associations; Disability; Package; Pain
ISSN (print) / ISBN
1063-4584
e-ISSN
1063-4584
Zeitschrift
Osteoarthritis and Cartilage
Quellenangaben
Band: 32,
Heft: 9,
Seiten: 1126-1133
Verlag
Elsevier
Verlagsort
125 London Wall, London, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Translational Genomics (ITG)