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Decoding the genomic enigma: Approaches to studying extrachromosomal circular DNA.
Heliyon 10:e36659 (2024)
Extrachromosomal circular DNA (eccDNA), a pervasive yet enigmatic component of the eukaryotic genome, exists autonomously from its chromosomal counterparts. Ubiquitous in eukaryotes, eccDNA plays a critical role in the orchestration of cellular processes and the etiology of diseases, particularly cancers. However, the full scope of its influence on health and disease remains elusive, presenting a rich vein of research yet to be mined. Unraveling the complexities of eccDNA necessitates a distillation of methodologies — from biogenesis to functional analysis — a landscape we overview in this study with precision and clarity. Here, we systematically outline cutting-edge methodologies from high-throughput sequencing and bioinformatics to experimental validations, showcasing the intricate world of eccDNAs. We combed through a treasure trove of auxiliary research resources and analytical tools. Moreover, we chart a course for future inquiry, illuminating the horizon with potential groundbreaking strategies for designing eccDNA research projects and pioneering new methodological frontiers.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Analytical Tool ; Approach ; Eccdna ; Ecdna ; Experimental Method ; Extrachromosomal Circular Dna ; High-throughput Sequencing ; Methodology ; Single Cell; Evolution; Shape
ISSN (print) / ISBN
2405-8440
e-ISSN
2405-8440
Zeitschrift
Heliyon
Quellenangaben
Band: 10,
Heft: 17,
Artikelnummer: e36659
Verlag
Elsevier
Verlagsort
London [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Analytical Pathology (AAP)
Förderungen
Guangzhou Basic and Applied Basic Research Foundation
Science and Technology Planning Project of Guangdong Province
Fundamental Research Funds for the Central Universities
(Guangdong-Dongguan Joint Fund)
Guangzhou Basic and Applied Basic Research Foundation
Science and Technology Planning Project of Guangdong Province
Fundamental Research Funds for the Central Universities
(Guangdong-Dongguan Joint Fund)