Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages.
Nanomed. 7, 855-865 (2012)
Aim: To investigate the relationship of alveolar macrophages and inhaled nanoparticles in the lung. Materials & methods: Rats were exposed by inhalation to 14 nm gold nanoparticles for 6 hours, and ultramicroscopic observation on the frequency and localization of gold nanoparticles within lavaged macrophages was performed up to 7 days. Results & discussion: The majority of macrophages examined on day 0 (94%) contained internalized gold nanoparticles, and the percentage decreased to 59% on day 7. Gold nanoparticles were exclusively found within cytoplasmic vesicles. On day 0, most gold nanoparticles appeared to be individual or slightly agglomerated, and they were frequently agglomerated on day 7. Conclusion: Alveolar macrophages efficiently internalized nanoparticles by endocytosis, and re-arrangements of vesicles and of nanoparticles in the vesicles of macrophages occurred.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
nanoparticle, inhalation, gold, alveolar macrophage, internalization; cellular trafficking
ISSN (print) / ISBN
1743-5889
e-ISSN
1748-6963
Zeitschrift
Nanomedicine
Quellenangaben
Band: 7,
Heft: 6,
Seiten: 855-865
Verlag
Future Medicine
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed