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Kopaliani, I.* ; Elsaid, B.* ; Speier, S. ; Deussen, A.*

Immune and metabolic mechanisms of endothelial dysfunction.

Int. J. Mol. Sci. 25:13337 (2024)
Verlagsversion DOI PMC
Free journal
Creative Commons Lizenzvertrag
Endothelial dysfunction is a strong prognostic factor in predicting the development of cardiovascular diseases. Dysfunctional endothelium loses its homeostatic ability to regulate vascular tone and prevent overactivation of inflammation, leading to vascular dysfunction. These functions are critical for vascular homeostasis and arterial pressure control, the disruption of which may lead to hypertension. Hypertension itself can also cause endothelial dysfunction, as endothelial cells are susceptible to haemodynamic changes. Although it is unclear which of those factors appear first, they create a vicious circle further damaging multiple organs, including the heart and vessels. There are also sex-specific differences in homeostatic functions of the endothelium regarding vessel tone regulation, which may contribute to differences in arterial blood pressure between men and women. Even more importantly, there are sex-differences in the development of endothelial dysfunction and vessel remodelling. Hence, an understanding of the mechanisms of endothelial dysfunction and its contribution to pathological vascular remodelling during hypertension is of critical importance. This review addresses immunological and metabolic aspects in mechanisms of endothelial dysfunction and the resulting mechanisms in vascular remodelling with respect to arterial hypertension, including the potential role of sex-specific differences.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Endothelial Dysfunction ; Endothelium ; Hypertension ; Inflammation ; Metabolism ; Sex-differences ; Vessel Remodelling; Vascular Smooth-muscle; Porcine Coronary-arteries; Nitric-oxide Synthesis; Angiotensin-ii; Blood-pressure; Asymmetric Dimethylarginine; Gender-differences; Cardiac Rehabilitation; Hyperpolarizing Factor; Sex-differences
ISSN (print) / ISBN 1422-0067
e-ISSN 1661-6596
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 25, Heft: 24, Seiten: , Artikelnummer: 13337 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen Deutsche Forschungsgemeinschaft
Irakli Kopaliani from the Deutsche Forschungsgemeinschaft