Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women.
Neuroendocrinology 97, 176-182 (2013)
Aim: There is accumulating evidence that food consumption is controlled by a wide range of brain circuits outside of the homeostatic system. Activation in these brain circuits may override the homeostatic system and also contribute to the enormous increase of obesity. However, little is known about the influence of hormonal signals on the brain's non-homeostatic system. Thus, selective insulin action in the brain was investigated by using intranasal application. Methods: We performed 'resting-state' functional magnetic resonance imaging in 17 healthy lean female subjects to assess intrinsic brain activity by fractional amplitude of low-frequency fluctuations (fALFF) before, 30 and 90 min after application of intranasal insulin. Results: Here, we showed that insulin modulates intrinsic brain activity in the hypothalamus and orbitofrontal cortex. Furthermore, we could show that the prefrontal and anterior cingulate cortex response to insulin is associated with body mass index. Conclusion: This demonstrates that hormonal signals as insulin may reduce food intake by modifying the reward and prefrontal circuitry of the human brain, thereby potentially decreasing the rewarding properties of food. Due to the alarming increase in obesity worldwide, it is of great importance to identify neural mechanisms of interaction between the homeostatic and non-homeostatic system to generate new targets for obesity therapy.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Resting-state functional magnetic resonance imaging; Insulin; Obesity; Food reward; Central-nervous-system ; Low-frequency Fluctuation ; State Functional Mri ; Glucose-ingestion ; Food-intake ; Dopamine Transporter ; Orbitofrontal Cortex ; Messenger-rna ; Obesity ; Memory
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2013
Prepublished im Jahr
2012
HGF-Berichtsjahr
2012
ISSN (print) / ISBN
0028-3835
e-ISSN
1423-0194
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 97,
Heft: 2,
Seiten: 176-182
Artikelnummer: ,
Supplement: ,
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Verlag
Karger
Verlagsort
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
90000 - German Center for Diabetes Research
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502400-001
Förderungen
Copyright
Erfassungsdatum
2012-11-29