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Schmidt, J. ; Panzilius, E. ; Bartsch, H.S.* ; Irmler, M. ; Beckers, J. ; Kari, V.* ; Linnemann, J. ; Dragoi, D. ; Hirschi, B. ; Kloos, U. ; Sass, S. ; Theis, F.J. ; Kahlert, S.* ; Johnsen, S.A.* ; Sotlar, K.* ; Scheel, C.

Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation.

Cell Rep. 10, 131-139 (2015)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Master regulators of the epithelial-mesenchymal transition such as Twist1 and Snail1 have been implicated in invasiveness and the generation of cancer stem cells, but their persistent activity inhibits stem-cell-like properties and the outgrowth of disseminated cancer cells into macroscopic metastases. Here, we show that Twist1 activation primes a subset of mammary epithelial cells for stem-cell-like properties, which only emerge and stably persist following Twist1 deactivation. Consequently, when cells undergo a mesenchymal-epithelial transition (MET), they do not return to their original epithelial cell state, evidenced by acquisition of invasive growth behavior and a distinct gene expression profile. These data provide an explanation for how transient Twist1 activation may promote all steps of the metastatic cascade; i.e., invasion, dissemination, and metastatic outgrowth at distant sites.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Promotes Metastatic Colonization; Mesenchymal Transition; Breast-cancer; E-cadherin; Expression; Generation; Requires; Emt
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 10, Heft: 2, Seiten: 131-139 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
Institute of Experimental Genetics (IEG)
Institute of Computational Biology (ICB)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30201 - Metabolic Health
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Stem Cell and Neuroscience
Genetics and Epidemiology
Enabling and Novel Technologies
PSP-Element(e) G-552300-001
G-500600-004
G-503800-001
PubMed ID 25578726
DOI 10.1016/j.celrep.2014.12.032
WOS ID WOS:000348036600002
Scopus ID 84920942890
Scopus ID 84920542504
Erfassungsdatum 2015-01-14
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