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Reagan, A.* ; Gu, X.* ; Hauck, S.M. ; Ash, J.D.* ; Cao, G.* ; Thompson, T.C.* ; Elliott, M.H.*

Retinal caveolin-1 modulates neuroprotective signaling.

Adv. Exp. Med. Biol. 854, 411-418 (2016)
Postprint DOI PMC
Open Access Green
Caveolin-1 (Cav-1), the scaffolding protein of caveolae, is expressed in several retinal cell types and is associated with ocular pathologies. Cav-1 modulates neuroinflammatory/neuroprotective responses to central nervous system injury. We have shown that loss of Cav-1 results in a blunted cytokine response in retinas challenged with inflammatory stimuli. As neuroinflammatory and neuroprotective signaling overlap in their cytokine production and downstream signaling pathways, we hypothesized that loss of Cav-1 may also suppress neuroprotective signaling in the retina. To test this, we subjected mice in which Cav-1 was deleted specifically in the retina to a neurodegenerative insult induced by sodium iodate (NaIO3) and measured STAT3 activation, a measure of neuroprotective signaling. Our results show that Cav-1 ablation blunts STAT3 activation induced by NaIO3. STAT3 activation in response to intravitreal administration of the IL-6 family cytokine, leukemia inhibitory factor (LIF), was not affected by Cav-1 deletion indicating a competent gp130 receptor response. Thus, Cav-1 modulates neuroprotective signaling by regulating the endogenous production of neuroprotective factors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Herausgeber Bowes Rickman, C.* ; LaVail, M.M.* ; Anderson, R.E.* ; Grimm, C.* ; Hollyfield, J.G.* ; Ash, J.*
Korrespondenzautor
Schlagwörter Caveolin-1 ; Cre/lox ; Conditional Knockout ; Neuroprotection ; Cytokines ; Sodium Iodate ; Stat3; Breakdown; Barrier
ISSN (print) / ISBN 0065-2598
Konferenztitel Retinal Degenerative Diseases : Mechanisms and Experimental Therapy
Zeitschrift Advances in Experimental Medicine and Biology
Quellenangaben Band: 854, Heft: , Seiten: 411-418 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)