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Hachmöller, O.* ; Buzanich, A.G.* ; Aichler, M. ; Radtke, M.* ; Dietrich, D.* ; Schwamborn, K.* ; Lutz, L.* ; Werner, M.* ; Sperling, M.* ; Walch, A.K. ; Karst, U.*

Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μXRF and XANES.

Metallomics 8, 648-653 (2016)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
A liver biopsy specimen from a Wilson's disease (WD) patient was analyzed by means of micro-X-ray fluorescence (μXRF) spectroscopy to determine the elemental distribution. First, bench-top μXRF was utilized for a coarse scan of the sample under laboratory conditions. The resulting distribution maps of copper and iron enabled the determination of a region of interest (ROI) for further analysis. In order to obtain more detailed elemental information, this ROI was analyzed by synchrotron radiation (SR)-based μXRF with a beam size of 4 μm offering a resolution at the cellular level. Distribution maps of additional elements to copper and iron like zinc and manganese were obtained due to a higher sensitivity of SR-μXRF. In addition to this, X-ray absorption near edge structure spectroscopy (XANES) was performed to identify the oxidation states of copper in WD. This speciation analysis indicated a mixture of copper(i) and copper(ii) within the WD liver tissue.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ray-fluorescence Microscopy; Synchrotron-radiation; Oxidation-state; Copper; Gene; Spectroscopy; Spectrometry; Diagnosis; Atpase; Liver
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1756-5901
e-ISSN 1756-591X
Zeitschrift Metallomics
Quellenangaben Band: 8, Heft: 7, Seiten: 648-653 Artikelnummer: , Supplement: ,
Verlag Royal Society of Chemistry (RSC)
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Analytical Pathology (AAP)
Institute of Pathology (PATH)
POF Topic(s) 30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-500390-001
G-500300-001
DOI 10.1039/c6mt00001k
WOS ID WOS:000379572300003
Scopus ID 84978906435
PubMed ID 26999628
Erfassungsdatum 2016-03-23
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