Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
Publ. Version/Full Text
DOI
PMC
 |
Open Access Hybrid |
|
as soon as is submitted to ZB.
Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μXRF and XANES.
Metallomics 8, 648-653 (2016)
A liver biopsy specimen from a Wilson's disease (WD) patient was analyzed by means of micro-X-ray fluorescence (μXRF) spectroscopy to determine the elemental distribution. First, bench-top μXRF was utilized for a coarse scan of the sample under laboratory conditions. The resulting distribution maps of copper and iron enabled the determination of a region of interest (ROI) for further analysis. In order to obtain more detailed elemental information, this ROI was analyzed by synchrotron radiation (SR)-based μXRF with a beam size of 4 μm offering a resolution at the cellular level. Distribution maps of additional elements to copper and iron like zinc and manganese were obtained due to a higher sensitivity of SR-μXRF. In addition to this, X-ray absorption near edge structure spectroscopy (XANES) was performed to identify the oxidation states of copper in WD. This speciation analysis indicated a mixture of copper(i) and copper(ii) within the WD liver tissue.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
3.540
0.960
24
26
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ray-fluorescence Microscopy; Synchrotron-radiation; Oxidation-state; Copper; Gene; Spectroscopy; Spectrometry; Diagnosis; Atpase; Liver
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1756-5901
e-ISSN
1756-591X
Journal
Metallomics
Quellenangaben
Volume: 8,
Issue: 7,
Pages: 648-653
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
Cambridge
Reviewing status
Peer reviewed
POF-Topic(s)
30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-500390-001
G-500300-001
G-500300-001
WOS ID
WOS:000379572300003
Scopus ID
84978906435
PubMed ID
26999628
Erfassungsdatum
2016-03-23