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Ohnmacht, C.

Tolerance to the intestinal microbiota mediated by ROR(γt)+ cells.

Trends Immunol. 37, 477-486 (2016)
Postprint DOI PMC
Open Access Green
Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. However, the immune system is primed to recognize both conserved microbial patterns and foreign antigens, and therefore developed strong tolerance mechanisms to prevent potential fatal immune reactivity to symbiotic microbes. The transcription factor RAR-related orphan-like γt [ROR(γt); encoded by Rorc] plays a key role in the gut for lymphoid tissue organogenesis, development of innate lymphoid cells type 3 (ILC3s) and proinflammatory type 17 T helper (Th17) cells. Surprisingly, recent research has revealed a contribution of ROR(γt)-expressing cells in a variety of tolerance mechanisms in both the innate and adaptive immune system.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Immunological Tolerance ; Rar-related Orphan Receptor γt ; Microbiota ; Regulatory T Cells; Innate Lymphoid-cells; Regulatory T-cells; Ror-gamma-t; Tissue-inducer Cells; Segmented Filamentous Bacteria; Cd103(+) Dendritic Cells; Pathogenic T(h)17 Cells; Th17 Cells; Commensal Bacteria; In-vivo
ISSN (print) / ISBN 1471-4906
e-ISSN 1471-4981
Zeitschrift Trends in Immunology
Quellenangaben Band: 37, Heft: 7, Seiten: 477-486 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)