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Tolerance to the intestinal microbiota mediated by ROR(γt)+ cells.
Trends Immunol. 37, 477-486 (2016)
Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. However, the immune system is primed to recognize both conserved microbial patterns and foreign antigens, and therefore developed strong tolerance mechanisms to prevent potential fatal immune reactivity to symbiotic microbes. The transcription factor RAR-related orphan-like γt [ROR(γt); encoded by Rorc] plays a key role in the gut for lymphoid tissue organogenesis, development of innate lymphoid cells type 3 (ILC3s) and proinflammatory type 17 T helper (Th17) cells. Surprisingly, recent research has revealed a contribution of ROR(γt)-expressing cells in a variety of tolerance mechanisms in both the innate and adaptive immune system.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
11.433
2.433
15
15
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Immunological Tolerance ; Rar-related Orphan Receptor γt ; Microbiota ; Regulatory T Cells; Innate Lymphoid-cells; Regulatory T-cells; Ror-gamma-t; Tissue-inducer Cells; Segmented Filamentous Bacteria; Cd103(+) Dendritic Cells; Pathogenic T(h)17 Cells; Th17 Cells; Commensal Bacteria; In-vivo
Sprache
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
1471-4906
e-ISSN
1471-4981
Zeitschrift
Trends in Immunology
Quellenangaben
Band: 37,
Heft: 7,
Seiten: 477-486
Verlag
Elsevier
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Allergy
PSP-Element(e)
G-505400-003
WOS ID
WOS:000379098200006
Scopus ID
84975165474
PubMed ID
27255270
Erfassungsdatum
2016-06-06