PuSH - Publikationsserver des Helmholtz Zentrums München: Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Fehringer, G.* ; Kraft, P.* ; Pharoah, P.D.* ; Eeles, R.A.* ; Chatterjee, N.* ; Schumacher, F.R.* ; Schildkraut, J.M.* ; Lindström, S.* ; Brennan, P.* ; Bickeböller, H.* ; Houlston, R.S.* ; Landi, M.T.* ; Caporaso, N.E.* ; Risch, A.* ; Amin Al Olama, A.* ; Berndt, S.I.* ; Giovannucci, E.* ; Grönberg, H.* ; Kote-Jarai, Z.* ; Ma, J.* ; Muir, K.* ; Stampfer, M.J.* ; Stevens, V.L.* ; Wiklund, F.* ; Willett, W.C.* ; Goode, E.L. ; Permuth, J.B.* ; Risch, H.A.* ; Reid, B.M.* ; Bézieau, S.* ; Brenner, H.* ; Chan, A.T.* ; Chang-Claude, J.* ; Hudson, T.J.* ; Kocarnik, J.M.* ; Newcomb, P.A.* ; Schoen, R.E.* ; Slattery, M.L.* ; White, E.S.* ; Adank, M.A.* ; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) (*) ; Ahsan, H.* ; Aittomäki, K.* ; Baglietto, L.* ; Blomquist, C.H.* ; Canzian, F.* ; Czene, K.* ; Dos Santos Silva, I.* ; Eliassen, A.H.* ; Figueroa, J.D.* ; Flesch-Janys, D.* ; Fletcher, O.* ; Garcia-Closas, M.* ; Gaudet, M.M.* ; Johnson, N.* ; Hall, P.* ; Hazra, A.* ; Hein, R.* ; Hofman, A.* ; Hopper, J.L.* ; Irwanto, A.* ; Johansson, M.* ; Kaaks, R.* ; Kibriya, M.G.* ; Lichtner, P. ; Liu, J.J.* ; Lund, E.* ; Makalic, E.* ; Meindl, A.* ; Müller-Myhsok, B.* ; Muranen, T.A.* ; Nevanlinna, H.* ; Peeters, P.H.* ; Peto, J.* ; Prentice, R.L.* ; Rahman, N.* ; Sánchez, M.J.* ; Schmidt, D.F.* ; Schmutzler, R.K.* ; Southey, M.C.* ; Tamimi, R.M.* ; Travis, R.C.* ; Turnbull, C.* ; Uitterlinden, A.G.* ; Wang, Z.* ; Whittemore, A.S.* ; Yang, X.R.* ; Zheng, W.* ; Rafnar, T.* ; Gudmundsson, J.* ; Stacey, S.N.* ; Stefansson, K.* ; Sulem, P.* ; Chen, Y.A.* ; Tyrer, J.P.* ; Christiani, D.C.* ; Wei, Y.* ; Shen, H.* ; Hu, Z.* ; Shu, X.O.* ; Shiraishi, K.* ; Takahashi, A.* ; Bossé, Y.* ; Obeidat, M.* ; Nickle, D.C.* ; Timens, W.* ; Freedman, M.L.* ; Li, Q.L.* ; Seminara, D.* ; Chanock, S.J.* ; Gong, J.* ; Peters, U.* ; Gruber, S.B.* ; Colorectal Transdisciplinary Study (CORECT) (*) ; Amos, C.I.* ; Sellers, T.A.* ; Easton, D.F.* ; Hunter, D.J.* ; Haiman, C.A.* ; African American Breast Cancer Consortium (AABC) (*) ; African Ancestry Prostate Cancer Consortium (AAPC) (*) ; Henderson, B.E.* ; Hung, R.J.*

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations.

Cancer Res. 76, 5103-5114 (2016)

Verlagsversion

Postprint

Forschungsdaten

DOI

PMC

	Open Access Green

Abstract
Metriken
Zusatzinfos

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

8.556

1.921