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Early injury of the neonatal lung contributes to premature lung aging: A hypothesis.
Mol. Cell. Pediatr. 3:24 (2016)
Chronic lung disease of the newborn, also known as bronchopulmonary dysplasia (BPD), is the most common chronic lung disease in early infancy and results in an increased risk for long-lasting pulmonary impairment in the adult. BPD develops upon injury of the immature lung by oxygen toxicity, mechanical ventilation, and infections which trigger sustained inflammatory immune responses and extensive remodeling of the extracellular matrix together with dysregulated growth factor signaling. Histopathologically, BPD is characterized by impaired alveolarization, disrupted vascular development, and saccular wall fibrosis. Here, we explore the hypothesis that development of BPD involves disturbance of conserved pathways of molecular aging that may contribute to premature aging of the lung and an increased susceptibility to chronic lung diseases in adulthood.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Bpd Premature Aging ; Early Injury ; Hyperoxia ; Immature Lung
Sprache
englisch
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
2194-7791
Zeitschrift
Molecular and Cellular Pediatrics
Quellenangaben
Band: 3,
Heft: 1,
Artikelnummer: 24
Verlag
Springer
Verlagsort
Berlin ; Heidelberg [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Health and Immunity (LHI)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Lung Research
PSP-Element(e)
G-552100-001
G-501600-004
G-501600-004
Scopus ID
105005123162
PubMed ID
27406259
Erfassungsdatum
2016-07-21