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Ota, C. ; Baarsma, H.A. ; Wagner, D.E. ; Hilgendorff, A. ; Königshoff, M.

Linking bronchopulmonary dysplasia to adult chronic lung diseases: Role of WNT signaling.

Mol. Cell. Pediatr. 3, 34:34 (2016)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adult Chronic Lung Diseases ; Bronchopulmonary Dysplasia (bpd) ; Lung Development ; Wnt Signaling
Sprache deutsch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 0
ISSN (print) / ISBN 2194-7791
Zeitschrift Molecular and Cellular Pediatrics
Quellenangaben Band: 3, Heft: , Seiten: 34 Artikelnummer: 34 Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-551800-001
G-552100-001
PubMed ID 27718180
DOI 10.1186/s40348-016-0062-6
Erfassungsdatum 2016-10-17
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