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Brandl, C.* ; Breinlich, V.* ; Stark, K.J.* ; Enzinger, S.* ; Aßenmacher, M.* ; Olden, M.* ; Grassmann, F.* ; Graw, J. ; Heier, M. ; Peters, A. ; Helbig, H.* ; Küchenhoff, H.* ; Weber, B.H.F.* ; Heid, I.M.

Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study.

PLoS ONE 11:e0167181 (2016)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50 years of age. However, there is little knowledge to what extent also younger adults are affected. We have thus set out to estimate the prevalence of early AMD features and late AMD in a general adult population by acquiring color fundus images in 2,840 individuals aged 25 to 74 years of the Cooperative Health Research in the Region of Augsburg project (KORA) in South Germany. Among the 2,546 participants with gradable images for each eye, 10.9% (n = 277) had early AMD features (applying the 9-step Age-Related Eye Disease Study Severity Scale), 0.2% (n = 6) had late AMD. Prevalence increased with age, reaching 26.3% for early AMD features and 1.9% for late AMD at the age 70+. However, signs of early AMD were found in subjects as young as 25 years, with the risk for early AMD features increasing linearly by years of age in men, and, less consistent with a linear increase, in women. Risk for early AMD features increased linearly by pack years of smoking in men, not in women, nor was there any association with other lifestyle or metabolic factors. By providing much soughtafter prevalence estimates for AMD from Central Europe, our data underscores a substantial proportion of the adult population with signs of early AMD, including individuals younger than 50 years. This supports the notion that early AMD features in the young might be under-acknowledged.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Blue Mountains Eye; Cardiovascular Risk-factors; Long-term Incidence; Severity Scale; Regression Splines; 10-year Incidence; Cataract-surgery; Pooled Findings; Grading System; 3 Continents
Sprache deutsch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 11, Heft: 11, Seiten: , Artikelnummer: e0167181 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30204 - Cell Programming and Repair
30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-001
G-500500-002
G-504000-006
G-504100-001
G-504090-001
DOI 10.1371/journal.pone.0167181
WOS ID WOS:000389472400096
Scopus ID 84998827977
Erfassungsdatum 2016-12-13
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