Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography.
    
    
        
    
    
        
        Proc. SPIE 10064:100641B (2017)
    
    
    
		
		
			
				Due to modeling and experimental imperfections, multispectral optoacoustic tomography images are often afflicted with negative values, which are further amplified when propagating into the spectrally unmixed images of chromophore concentrations. Since negative values have no physical meaning, accuracy can potentially be improved by imposing non-negativity constraints on the initial reconstructions and the unmixing steps. Herein, we compare several non-negative constrained approaches with reconstruction and spectral unmixing performed separately or combined in a single inverse step. The quantitative performance and sensitivity of the different approaches in detecting small amounts of spectrally-distinct chromophores are studied in tissue-mimicking phantoms and mouse experiments.
			
			
				
			
		 
		
			
				
					
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
    
        Typ der Hochschulschrift
        
    
 
    
        Herausgeber
        
    
    
        Schlagwörter
        Optoacoustic/photoacoustic tomography, multispectral imaging, spectral unmixing, non-negative constraint
    
 
    
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        Veröffentlichungsjahr
        2017
    
 
    
        Prepublished im Jahr 
        
    
 
    
        HGF-Berichtsjahr
        2017
    
 
    
    
        ISSN (print) / ISBN
        0277-786X
    
 
    
        e-ISSN
        1996-756X
    
 
    
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        Konferenztitel
        Photons Plus Ultrasound: Imaging and Sensing 2017
    
 
	
        Konferzenzdatum
        28 January - 2 February 2017
    
     
	
        Konferenzort
        San Francisco, California, United States
    
 
	
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        Quellenangaben
        
	    Band: 10064,  
	    Heft: ,  
	    Seiten: ,  
	    Artikelnummer: 100641B 
	    Supplement: ,  
	
    
 
  
        
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        Begutachtungsstatus
        Peer reviewed
    
 
     
    
        POF Topic(s)
        30205 - Bioengineering and Digital Health
    
 
    
        Forschungsfeld(er)
        Enabling and Novel Technologies
    
 
    
        PSP-Element(e)
        G-505590-001
    
 
    
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        Erfassungsdatum
        2017-03-20