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Scherer, K.* ; Yaroshenko, A.* ; Bölükbas, D.A. ; Gromann, L.B.* ; Hellbach, K.* ; Meinel, F.G.* ; Braunagel, M.* ; Berg, J.V.* ; Eickelberg, O. ; Reiser, M.F.* ; Pfeiffer, F.* ; Meiners, S. ; Herzen, J.*

X-ray dark-field radiography - in-vivo diagnosis of lung cancer in mice.

Sci. Rep. 7:402 (2017)

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Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this method still needs to be adapted to larger mammals and finally humans, the technique presented here can already serve as a valuable tool in evaluating novel lung cancer therapies, tested in mice and other small animal models.

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