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Ko, C. ; Michler, T. ; Protzer, U.

Novel viral and host targets to cure hepatitis B.

Curr. Opin. Virol. 24, 38-45 (2017)
Postprint DOI PMC
Open Access Green
Hepatitis B virus (HBV) infection is a global health threat with 240 million chronic carriers at high risk to develop hepatocellular carcinoma. Current antiviral treatment can efficiently control viral replication and reduce liver inflammation, but is still quite far from achieving a cure. Significant progress has been made in understanding the virus life cycle and virus-host interaction in the past few years. With identification of the HBV receptor, cell-culture infection systems have become available that allow drug screening and establishing a pipeline of potential antivirals targeting either viral or host factors. Most of the candidate antivirals summarized in this review are still in preclinical development, but some have already entered or are about to enter early clinical trials.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Virus X Protein; Nonhepatotoxic Degradation; Hepatocellular-carcinoma; Reverse-transcriptase; Restriction Factor; Gene-expression; Cccdna Function; Analog Therapy; Reduced Risk; Hbx Protein
Sprache
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1879-6257
e-ISSN 1879-6265
Zeitschrift Current Opinion in Virology
Quellenangaben Band: 24, Heft: , Seiten: 38-45 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-003
DOI 10.1016/j.coviro.2017.03.019
WOS ID WOS:000407412700007
Scopus ID 85018495443
PubMed ID 28433762
Erfassungsdatum 2017-07-04
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