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Cusan, M. ; Vegi, N.M.* ; Mulaw, M.A.* ; Bamezai, S.* ; Kaiser, L.M.* ; Deshpande, A.J.* ; Greif, P.A. ; Quintanilla-Fend, L.* ; Göllner, S.* ; Müller-Tidow, C.* ; Humphries, K.R.* ; Armstrong, S.A.* ; Hiddemann, W. ; Feuring-Buske, M.* ; Buske, C.*

Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus.

Blood 129, 319-323 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
There is high interest in understanding the mechanisms that drive self-renewal of stem cells. HOXB4 is one of the few transcription factors that can amplify long-term repopulating hematopoietic stem cells in a controlled way. Here we show in mice that this characteristic of HOXB4 depends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly conserved in higher mammals. Deletion of this domain substantially enhanced the oncogenicity of HOXB4, inducing acute leukemia in mice. Conversely, insertion of the domain into Hoxa9 impaired leukemogenicity of this homeobox gene. These results indicate that proline-rich stretches attenuate the potential of stem cell active homeobox genes to acquire oncogenic properties.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 129, Heft: 3, Seiten: 319-323 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Begutachtungsstatus Peer reviewed
Institut(e) CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)