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Garcia-Molina, A.* ; Altmann, M.* ; Alkofer, A.* ; Epple, P.M.* ; Dangl, J.L.* ; Falter-Braun, P.

LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.

J. Exp. Bot. 68, 1185-1197 (2017)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
In natural environments, plants often experience different stresses simultaneously, and adverse abiotic conditions can weaken the plant immune system. Interactome mapping revealed that the LOW SULPHUR UPREGULATED (LSU) proteins are hubs in an Arabidopsis protein interaction network that are targeted by virulence effectors from evolutionarily diverse pathogens. Here we show that LSU proteins are up-regulated in several abiotic and biotic stress conditions, such as nutrient depletion or salt stress, by both transcriptional and post-translational mechanisms. Interference with LSU expression prevents chloroplastic reactive oxygen species (ROS) production and proper stomatal closure during sulphur stress. We demonstrate that LSU1 interacts with the chloroplastic superoxide dismutase FSD2 and stimulates its enzymatic activity in vivo and in vitro. Pseudomonas syringae virulence effectors interfere with this interaction and preclude re-localization of LSU1 to chloroplasts. We demonstrate that reduced LSU levels cause a moderately enhanced disease susceptibility in plants exposed to abiotic stresses such as nutrient deficiency, high salinity, or heavy metal toxicity, whereas LSU1 overexpression confers significant disease resistance in several of these conditions. Our data suggest that the network hub LSU1 plays an important role in co-ordinating plant immune responses across a spectrum of abiotic stress conditions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Abiotic Stress ; Arabidopsis Thaliana ; Biotic Stress ; Combinatorial Stress ; Low Sulphur Upregulated ; Lsu1; Induced Stomatal Closure; Plant Immune-system; Abscisic-acid; Hydrogen-peroxide; Guard-cells; Arabidopsis-thaliana; Drought Stress; Pseudomonas-syringae; Disease Resistance; Oxidative Stress
ISSN (print) / ISBN 0022-0957
e-ISSN 1460-2431
Zeitschrift Journal of Experimental Botany
Quellenangaben Band: 68, Heft: 5, Seiten: 1185-1197 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Network Biology (INET)