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Dreher, C.* ; Habermehl, D. ; Jäkel, O.* ; Combs, S.E.

Effective radiotherapeutic treatment intensification in patients with pancreatic cancer: Higher doses alone, higher RBE or both?

Radiat. Oncol. 12:203 (2017)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Pancreatic cancer, especially in case of locally advanced stage has a poor prognosis. Radiotherapy in general can lead to tumor volume reduction, but further improvements, such as ion beam therapy have to be promoted in order to enable dose escalation, which in turn results in better local control rates and downsizing of the tumor itself. Ion beam therapy with its highly promising physical properties is also accompanied by distinct inter- and intrafractional challenges in case of robustness. First clinical results are promising, but further research in motion mitigation and biological treatment planning is necessary, in order to determine the best clinical rationales and conditions of ion beam therapy of pancreatic cancer. This review summarizes the current knowledge and studies on ion beam therapy of pancreatic cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Carbon Ions ; Ion Beam Therapy ; Pancreatic Cancer ; Particle Radiotherapy ; Protons ; Rbe; Stereotactic Body Radiotherapy; Carbon-ion Radiotherapy; Proton-beam Therapy; Radiation-therapy; Fractionated Chemoradiation; Duodenal Toxicity; Target Volume; Spinal-cord; Dosimetric Analysis; Motion Mitigation
Sprache
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1748-717X
e-ISSN 1748-717X
Zeitschrift Radiation Oncology
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 203 Supplement: ,
Verlag BioMed Central
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501300-001
PubMed ID 29282139
DOI 10.1186/s13014-017-0945-2
WOS ID WOS:000419159400001
Scopus ID 85039912183
Erfassungsdatum 2018-01-11
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