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Camps, G.* ; Veit, R. ; Mars, M.* ; de Graaf, C.* ; Smeets, P.A.*

Just add water: Effects of added gastric distention by water on gastric emptying and satiety related brain activity.

Appetite 127, 195-202 (2018)
Postprint DOI PMC
Open Access Green
Background: Gastric distention contributes to meal termination. There is little research on the neural correlates of gastric distention by food. To date, neural measures have not been obtained concurrently with measurements of gastric distention.Objectives: 1) To study how offering a small versus a large water load following a standardized nutrient load affects gastric distention over time. 2) To assess associations between satiety experiences and brain activity and the degree of gastric distention.Method: 19 healthy males (age 22.2 +/- 2.5 y, BMI 21.8 +/- 1.5 kg/m(2)) participated in a randomized crossover study with two treatments: ingestion of a 500-kcal 150-mL liquid meal shake followed by a low (LV, 50 mL) or a high volume (HV, 350 mL) water load. At baseline and three times after ingestion satiety was scored, MRI scans were made to determine total gastric content volume (TGV) and functional MRI scans were made to measure cerebral blood flow (CBF).Results: TGV was significantly higher for HV compared to LV at all time points (p < 0.001) with relative differences between HV and LV of 292 +/- 37 mL after ingestion, 182 +/- 83 mL at t = 15 min and 62 +/- 57 mL at t = 35 min. Hunger decreased (p = 0.023) and fullness increased (p = 0.030) significantly more for HV compared to LV. Ingestion increased CBF in the inferior frontal gyrus and the anterior insula, but there were no differences between treatments. There were no significant correlations between appetite ratings and CBF values.Conclusion: Performing concurrent gastric MRI and CBF measurements can be used to investigate neural correlates of gastric distention. Increased distention did not induce significantly greater brain activation. Future research should further examine the role of the inferior frontal gyrus in satiety.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Gastric Distention ; Gastric Mri ; Perfusion Mri ; Gastric Emptying ; Distention ; Fullness; Food-intake; Energy-intake; Gut Hormones; Weight-loss; Balloon Distension; Healthy Humans; Drinking-water; Bite Size; Meal; Satiation
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0195-6663
e-ISSN 1095-8304
Zeitschrift Appetite
Quellenangaben Band: 127, Heft: , Seiten: 195-202 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
DOI 10.1016/j.appet.2018.04.023
WOS ID WOS:000437384300022
Scopus ID 85046795140
PubMed ID 29730186
Erfassungsdatum 2018-06-25
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