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Simon, J.J.* ; Becker, A.* ; Sinno, M.H.* ; Skunde, M.* ; Bendszus, M.* ; Preissl, H. ; Enck, P.* ; Herzog, W.* ; Friederich, H.*

Neural food reward processing in successful and unsuccessful weight maintenance.

Obesity 26, 895-902 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Objective: Weight loss maintenance is one of the biggest challenges in behavioral weight loss programs. The present study aimed to examine metabolic influences on the mesolimbic reward system in people with successful and unsuccessful long-term weight loss maintenance. Methods: Thirty-three women with obesity at least 6 months after the completion of a diet were recruited: seventeen women were able to maintain their weight loss, whereas sixteen showed weight regain. Using functional magnetic resonance imaging in combination with the assessment of appetite-regulating hormones, neural reward processing during hunger and satiety was investigated. An incentive delay task was employed to investigate the expectation and receipt of both food-related and monetary reward. Results: Only participants with successful weight loss maintenance showed a satiety-induced attenuation of brain activation during the receipt of a food-related reward. Furthermore, in successful weight loss maintenance, the attenuation of active ghrelin levels was related to brain activation in response to food-related reward anticipation during satiety. Conclusions: The findings suggest that an attenuated influence of satiety signaling on the neural processing of food-related reward contributes to unsuccessful weight loss maintenance. Thus, intact satiety signaling to the mesolimbic reward system may serve as a promising target for tackling weight cycling.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Pseudomonas-putida F1; Saturated Porous-media; Aromatic-hydrocarbons; Anaerobic Degradation; Bacterial Communities; Toluene Degradation; Natural Attenuation; Transport; Aquifer; Kinetics
ISSN (print) / ISBN 1930-7381
e-ISSN 1930-739X
Zeitschrift Obesity
Quellenangaben Band: 26, Heft: 5, Seiten: 895-902 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 233 Spring St, New York, Ny 10013 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes and Obesity (IDO)