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Rodriguez-Calvo, T. ; Richardson, S.J.* ; Pugliese, A.*

Pancreas pathology during the natural history of type 1 diabetes.

Curr. Diab. Rep. 18:124 (2018)
Postprint DOI PMC
Open Access Green
Purpose of review We provide an overview of pancreas pathology in type 1 diabetes (T1D) in the context of its clinical stages.Recent findings Recent studies of pancreata from organ donors with T1D and non-diabetic donors expressing T1D-associated autoantibodies reveal pathological changes/disease mechanisms beyond the well-known loss of beta cells and lymphocytic infiltrates of the islets (insulitis), including beta-cell stress, dysfunction, and viral infections. Pancreas pathology evolves through disease stages, is asynchronous, and demonstrates a chronic disease that remains active years after diagnosis. Critically, beta-cell loss is not complete at onset, although young age is associated with increased severity.SummaryThe recognition of multiple pathogenic alterations and the chronic nature of disease mechanisms during and after the development of T1D inform improved clinical trial design and reveal additional targets for therapeutic manipulation, in the context of an expanded time window for intervention.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Type 1 Diabetes ; Insulitis ; Beta Cell ; Pancreas ; Islet Autoimmunity; Endoplasmic-reticulum Stress; Capsid Protein Vp1; Beta-cell Function; Islet Inflammation; Er Stress; C-peptide; T-cells; Insulin Microsecretors; Hyaluronan Synthesis; Biopsy Specimens
Sprache
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Zeitschrift Current Diabetes Reports
Quellenangaben Band: 18, Heft: 11, Seiten: , Artikelnummer: 124 Supplement: ,
Verlag Springer
Verlagsort Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502190-001
DOI 10.1007/s11892-018-1084-3
WOS ID WOS:000446536300002
Scopus ID 85054462565
PubMed ID 30293191
Erfassungsdatum 2018-10-22
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