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Bruns, O.T. ; Bischof, T.S.* ; Harris, D.K.* ; Franke, D.* ; Shi, Y.* ; Riedemann, L.* ; Bartelt, A.* ; Jaworski, F.B.* ; Carr, J.A.* ; Rowlands, C.J.* ; Wilson, M.W.B.* ; Chen, O.* ; Wei, H.* ; Hwang, G.W.* ; Montana, D.M.* ; Coropceanu, I.* ; Achorn, O.B.* ; Kloepper, J.* ; Heeren, J.* ; So, P.T.C.* ; Fukumura, D.* ; Jensen, K.F.* ; Jain, R.K.* ; Bawendi, M.G.*

Next-generation in vivo optical imaging with short-wave infrared quantum dots.

Nat. Bio. Eng. 1:0056 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
For imaging, the short-wavelength infrared region (SWIR; 1000-2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Zeitschrift Nature biomedical engineering
Quellenangaben Band: 1, Heft: , Seiten: , Artikelnummer: 0056 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London ; New York NY ; Tokyo
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
DOI 10.1038/s41551-017-0056
PubMed ID 29119058
Erfassungsdatum 2019-01-16
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