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Bruns, O.T. ; Bischof, T.S.* ; Harris, D.K.* ; Franke, D.* ; Shi, Y.* ; Riedemann, L.* ; Bartelt, A.* ; Jaworski, F.B.* ; Carr, J.A.* ; Rowlands, C.J.* ; Wilson, M.W.B.* ; Chen, O.* ; Wei, H.* ; Hwang, G.W.* ; Montana, D.M.* ; Coropceanu, I.* ; Achorn, O.B.* ; Kloepper, J.* ; Heeren, J.* ; So, P.T.C.* ; Fukumura, D.* ; Jensen, K.F.* ; Jain, R.K.* ; Bawendi, M.G.*

Next-generation in vivo optical imaging with short-wave infrared quantum dots.

Nat. Bio. Eng. 1:0056 (2017)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
For imaging, the short-wavelength infrared region (SWIR; 1000-2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Journal Nature biomedical engineering
Quellenangaben Volume: 1, Issue: , Pages: , Article Number: 0056 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London ; New York NY ; Tokyo
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)