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Breitner-Busch, S. ; Peters, A. ; Zareba, W.* ; Hampel, R. ; Oakes, D.* ; Wiltshire, J.* ; Frampton, M.W.* ; Hopke, P.K.* ; Cyrys, J. ; Utell, M.J.* ; Kane, C.* ; Schneider, A.E. ; Rich, D.Q.*

Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization.

Sci. Rep. 9:1946 (2019)

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Previous studies have reported increased risks of myocardial infarction in association with elevated ambient particulate matter (PM) in the previous hour(s). However, whether PM can trigger mechanisms that act on this time scale is still unclear. We hypothesized that increases in PM are associated with rapid changes in measures of heart rate variability and repolarization. We used data from panel studies in Augsburg, Germany, and Rochester, New York, USA, and two controlled human exposure studies in Rochester. Data included ECG recordings from all four studies, controlled exposures to (concentrated) ultrafine particles (UFP; particles with an aerodynamic diameter < 100 nm) and ambient concentrations of UFP and fine PM (PM2.5, aerodynamic diameter < 2.5 mu m). Factor analysis identified three representative ECG parameters: standard deviation of NN-intervals (SDNN), root mean square of successive differences (RMSSD), and T-wave complexity. Associations between air pollutants and ECG parameters in the concurrent and previous six hours were estimated using additive mixed models adjusting for long-and short-term time trends, meteorology, and study visit number. We found decreases in SDNN in relation to increased exposures to UFP in the previous five hours in both of the panel studies (e. g. Augsburg study, lag 3 hours: -2.26%, 95% confidence interval [ CI]: -3.98% to -0.53%; Rochester panel study, lag 1 hour: -2.69%; 95% CI: -5.13% to -0.26%) and one of the two controlled human exposure studies (1-hour lag: -13.22%; 95% CI: -24.11% to -2.33%). Similarly, we observed consistent decreases in SDNN and RMSSD in association with elevated PM2.5 concentrations in the preceding six hours in both panel studies. We did not find consistent associations between particle metrics and T-wave complexity. This study provided consistent evidence that recent exposures to UFP and PM2.5 can induce acute pathophysiological responses.

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