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Liu, C.T.* ; Merino, J.* ; Rybin, D.* ; DiCorpo, D.* ; Benke, K.S.* ; Bragg-Gresham, J.L.* ; Canouil, M.* ; Corre, T.* ; Grallert, H. ; Isaacs, A.* ; Kutalik, Z.* ; Lahti, J.* ; Marullo, L.* ; Marzi, C. ; Rasmussen-Torvik, L.J.* ; Rocheleau, G.* ; Rueedi, R.* ; Scapoli, C.* ; Verweij, N.* ; Vogelzangs, N.* ; Willems, S.M.* ; Yengo, L.* ; Bakker, S.J.L.* ; Beilby, J.* ; Hui, J.* ; Kajantie, E.* ; Müller-Nurasyid, M. ; Rathmann, W.* ; Balkau, B.* ; Bergmann, S.* ; Eriksson, J.G.* ; Florez, J.C.* ; Froguel, P.* ; Harris, T.* ; Hung, J.* ; James, A.L.* ; Kavousi, M.* ; Miljkovic, I.* ; Musk, A.W.* ; Palmer, L.J.* ; Peters, A. ; Roussel, R.* ; van der Harst, P.* ; van Duijn, C.M.* ; Vollenweider, P.* ; Barroso, I.* ; Prokopenko, I.* ; Dupuis, J.* ; Meigs, J.B.* ; Bouatia-Naji, N.*

Genome-wide association study of change in fasting glucose over time in 13,807 non-diabetic European Ancestry Individuals.

Sci. Rep. 9:9439 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we conducted a genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts. Fasting glucose change over time was defined as the slope of the line defined by multiple fasting glucose measurements obtained over up to 14 years of observation. We tested for associations of genetic variants with inverse-normal transformed fasting glucose change over time adjusting for age at baseline, sex, and principal components of genetic variation. We found no genome-wide significant association (P < 5 x 10(-8)) with fasting glucose change over time. Seven loci previously associated with T2D, fasting glucose or HbA1c were nominally (P < 0.05) associated with fasting glucose change over time. Limited power influences unambiguous interpretation, but these data suggest that genetic effects on fasting glucose change over time are likely to be small. A public version of the data provides a genomic resource to combine with future studies to evaluate shared genetic links with T2D and other metabolic risk traits.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Life-style Intervention; Genetic Architecture; Weight-loss; Type-2; Prevention; Variants; Risk; Loci; Population; Prediction
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 9, Heft: 1, Seiten: , Artikelnummer: 9439 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-002
G-504100-001
G-504000-010
DOI 10.1038/s41598-019-45823-7
WOS ID WOS:000473294100026
PubMed ID 31263163
Erfassungsdatum 2019-07-22
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