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Wang, X. ; Malinowski, A.R. ; Beckenbauer, J. ; Siehler, J. ; Blöchinger, A. ; Meitinger, T. ; Häring, H.-U. ; Staiger, H. ; Burtscher, I. ; Lickert, H.

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Stem Cell Res. 39:101531 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic beta-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method. The resulting iPSCs are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Furthermore, we show that this iPSC line can be differentiated into pancreatic lineage cells. Taken together, this iPSC line will be useful to test differentiation protocols towards beta-cell as well as other cell types and will also serve as a control for drug development and disease modelling studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 1873-5061
e-ISSN 1876-7753
Zeitschrift Stem Cell Research
Quellenangaben Band: 39, Heft: , Seiten: , Artikelnummer: 101531 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Regeneration Research (IDR)
Institute of Human Genetics (IHG)
Institute of Diabetes Research and Metabolic Diseases (IDM)