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Schuller, J.M.* ; Birrell, J.A.* ; Tanaka, H.* ; Konuma, T.* ; Wulfhorst, H.* ; Cox, N.* ; Schuller, S.K.* ; Thiemann, J.* ; Lubitz, W.* ; Sétif, P.* ; Ikegami, T.* ; Engel, B.D. ; Kurisu, G.* ; Nowaczyk, M.M.*

Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer.

Science 363, 257-260 (2019)
Verlagsversion DOI PMC
Free by Publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Photosynthetic complex I enables cyclic electron flow around photosystem I, a regulatory mechanism for photosynthetic energy conversion. We report a 3.3-angstrom-resolution cryo-electron microscopy structure of photosynthetic complex I from the cyanobacterium Thermosynechococcus elongatus. The model reveals structural adaptations that facilitate binding and electron transfer from the photosynthetic electron carrier ferredoxin. By mimicking cyclic electron flow with isolated components in vitro, we demonstrate that ferredoxin directly mediates electron transfer between photosystem I and complex I, instead of using intermediates such as NADPH (the reduced form of nicotinamide adenine dinucleotide phosphate). A large rate constant for association of ferredoxin to complex I indicates efficient recognition, with the protein subunit NdhS being the key component in this process.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 363, Heft: 6424, Seiten: 257-260 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)