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Li, Z.M. ; Albrecht, M.* ; Fromme, H.* ; Schramm, K.-W. ; de Angelis, M.

Persistent organic pollutants in human breast milk and associations with maternal thyroid hormone homeostasis.

Environ. Sci. Technol. 54, 1111-1119 (2020)
Postprint DOI PMC
Open Access Green
Epidemiological studies have indicated the thyroid-disrupting effects of persistent organic pollutants (POPs). However, the association of low-exposure POPs with thyroid hormones (THs) remains unclear. Here, we aim to assess the association of low exposure of POPs, including polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), and polybrominated dibenzo-p-dioxins and furans, with THs [total (L)-thyroxine (TT4), total 3,3',5-triiodo-L-thyronine (TT3), and total 3,3',5'-triiodo-(L)-thyronine (TrT3)] measured in human breast milk. Ninety-nine breast milk samples were collected from the LUPE cohort (2015-2016, Bavaria, Germany). Fourteen PBDEs, 17 PCBs, and 5 PCDD/Fs had quantification rates of >80%. Nonmonotonic associations were observed. In adjusted single-pollutant models, (1) TT4 was inversely associated with BDE-99,-154, and-196; (2) TT3 was inversely associated with BDE-47,-99,-100,-197,-203,-207, and OCDD; and (3) TrT3 was inversely associated with BDE-47, -99,-183, and -203. Multipollutant analysis using principal component analysis and hierarchical clustering revealed inverse associations of PBDEs (BDE-28,-47,-99,-100,-154,-183, and-197) with TT4 and TrT3. These results indicate that POPs at low levels might be related to reduced THs. This study shows that human breast milk might be an appropriate specimen to evaluate the thyroid disruption of POPs.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Polybrominated Diphenyl Ethers; Polychlorinated-biphenyls; Organochlorine Compounds; Flame Retardants; Nitro Musks; Cord-blood; Vitamin-a; Exposure; Pbdes; Pituitary
ISSN (print) / ISBN 0013-936X
e-ISSN 1520-5851
Zeitschrift Environmental Science & Technology
Quellenangaben Band: 54, Heft: 2, Seiten: 1111-1119 Artikelnummer: , Supplement: ,
Verlag ACS
Verlagsort Washington, DC
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) PPM-MEX-Molecular EXposomics (MEX)