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Prakash, J. ; Seyedebrahimi, M.M. ; Ghazaryan, A. ; Malekzadeh Najafabadi, J. ; Gujrati, V. ; Ntziachristos, V.

Short-wavelength optoacoustic spectroscopy based on water muting.

Proc. Natl. Acad. Sci. U.S.A. 117, 4007-4014 (2020)
Verlagsversion Postprint DOI PMC
Open Access Green
Infrared (IR) optoacoustic spectroscopy can separate a multitude of molecules based on their absorption spectra. However, the technique is limited when measuring target molecules in aqueous solution by strong water absorption at IR wavelengths, which reduces detection sensitivity. Based on the dependence of optoacoustic signal on the temperature of the probed medium, we introduce cooled IR optoacoustic spectroscopy (CIROAS) to mute water contributions in optoacoustic spectroscopy. We showcase that spectral measurements of proteins, lipids, and glucose in the short-wavelength IR region, performed at 4 degrees C, lead to marked sensitivity improvements over conventional optoacoustic or IR spectroscopy. We elaborate on the dependence of optoacoustic signals on water temperature and demonstrate polarity changes in the recorded signal at temperatures below 4 degrees C. We further elucidate the dependence of the optoacoustic signal and the muting temperature on sample concentration and demonstrate that changes in these dependences enable quantification of the solute concentration. We discuss how CIROAS may enhance abilities for molecular sensing in the IR.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Sensing ; Photoacoustics ; Near Infrared ; Temperature ; Spectroscopy; Photoacoustic-spectroscopy; Blood-glucose; Real-time; Temperature; Tomography; Brain; Density; Maximum
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 117, Heft: 8, Seiten: 4007-4014 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Verlagsort 2101 Constitution Ave Nw, Washington, Dc 20418 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
DOI 10.1073/pnas.1910597117
WOS ID WOS:000516771500023
Scopus ID 85080051054
PubMed ID 32029585
Erfassungsdatum 2020-02-26
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