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Vasiljevic, J. ; Torkko, J.M. ; Knoch, K.-P. ; Solimena, M.

The making of insulin in health and disease.

Diabetologia 63, 1981-1989 (2020)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes.Graphical abstract
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Beta Cell ; Insulin Biosynthesis ; Insulin Maturation ; Post-transcriptional Regulation ; Proinsulin Conversion ; Review ; Type 1 Diabetes ; Type 2 Diabetes; Endoplasmic-reticulum Stress; Rat Pancreatic-islets; Messenger-rna; Translational Control; Diabetes-mellitus; Er Stress; Proinsulin Synthesis; Granule Proteins; Gene-expression; Beta-cells
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Zeitschrift Diabetologia
Quellenangaben Band: 63, Heft: 10, Seiten: 1981-1989 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-001
Förderungen EU-IMI (INNODIA)
EU-IMI (RHAPSODY)
DOI 10.1007/s00125-020-05192-7
WOS ID WOS:000566764300004
Scopus ID 85090358574
PubMed ID 32894308
Erfassungsdatum 2020-10-27
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