PuSH - Publikationsserver des Helmholtz Zentrums München

Suarez, A.* ; Lahti, J.* ; Lahti-Pulkkinen, M.* ; Girchenko, P.* ; Czamara, D.* ; Knauer-Arloth, J. ; Malmberg, A.L.* ; Hämäläinen, E.* ; Kajantie, E.* ; Laivuori, H.* ; Villa, P.M.* ; Reynolds, R.M.* ; Provençal, N.* ; Binder, E.B.* ; Räikkönen, K.*

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders.

Neurobiol. Stress 13:100275 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: Maternal depression and anxiety during pregnancy may enhance fetal exposure to glucocorticoids (GCs) and harm neurodevelopment. We tested whether a novel cross-tissue polyepigenetic biomarker indicative of in utero exposure to GC is associated with mental and behavioral disorders and their severity in children, possibly mediating the associations between maternal prenatal depressive and anxiety symptoms and these child outcomes. Methods: Children (n = 814) from the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study were followed-up from birth to age 7.1–10.7 years. A weighted polyepigenetic GC exposure score was calculated based on the methylation profile of 24 CpGs from umbilical cord blood. Child diagnosis of mental and behavioral disorder (n = 99) and its severity, defined as the number of days the child had received treatment (all 99 had received outpatient treatment and 8 had been additionally in inpatient treatment) for mental or behavioral disorder as the primary diagnosis, came from the Care Register for Health Care. Mothers (n = 408) reported on child total behavior problems at child's age of 2.3–5.8 years and their own depressive and anxiety symptoms during pregnancy (n = 583). Results: The fetal polyepigenetic GC exposure score at birth was not associated with child hazard of mental and behavioral disorder (HR = 0.82, 95% CI 0.54; 1.24, p = 0.35) or total behavior problems (unstandardized beta = −0.10, 95% CI -0.31; 0.10, p = 0.33). However, for one standard deviation decrease in the polyepigenetic score, the child had spent 2.94 (95%CI 1.59; 5.45, p < 0.001) more days in inpatient or outpatient treatment with any mental and behavioral disorder as the primary diagnosis. Criteria for mediation tests were not met. Conclusions: These findings suggest that fetal polyepigenetic GC exposure score at birth was not associated with any mental or behavioral disorder diagnosis or mother-rated total behavior problems, but it may contribute to identifying children at birth who are at risk for more severe mental or behavioral disorders.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Childhood Mental Health ; Cord Blood Methylation ; Glucocorticoids ; Polyepigenetic Biomarker ; Prenatal Psychopathology ; Prospective Study; Maternal Licorice Consumption; Dna Methylation; Prenatal Stress; Psychiatric Outcomes; Depression; Pregnancy; Anxiety; Brain; Fetal; Metaanalysis
ISSN (print) / ISBN 2352-2895
e-ISSN 2352-2895
Zeitschrift Neurobiology of stress
Quellenangaben Band: 13, Heft: , Seiten: , Artikelnummer: 100275 Supplement: ,
Verlag Elsevier
Verlagsort Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen University of Helsinki Research Funds
European Union's Horizon 2020 Award
European Commission
Signe and Ane Gyllenberg Foundation
Orion Research Foundation
Emil Aaltonen Foundation
Finnish Medical Foundation
Jane and Aatos Erkko Foundation
Novo Nordisk Foundation
Paivikki and Sakari Sohlberg Foundation
Sigrid Juselius Foundation
Sir Jules Thorn Charitable Trust
Doctoral School of Psychology, Learning and Education
Academy of Finland