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Schuh, L. ; Loos, C. ; Pokrovsky, D.* ; Imhof, A.* ; Rupp, R.A.W.* ; Marr, C.

H4K20 methylation is differently regulated by dilution and demethylation in proliferating and cell-cycle-arrested xenopus embryos.

Cell Syst. 11, 653-662.e8 (2020)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
H4K20me kinetics in normal and cell-cycle-arrested Xenopus embryos. This quantitative model invokes specific methylation and unspecific demethylation and correctly predicts cell-cycle durations and cell-cycle dependencies. Active demethylation is not required to explain H4K20me kinetics of cycling cells, suggesting that overall H4K20me dilution through DNA replication is dominant. So only once cells stop cycling during embryogenesis, active H4K20 demethylation may contribute to shape histone methylation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Computational Modeling ; Demethylation ; Development ; Epigenetics ; Histone Post-translational Modifications ; Methylation Kinetics ; Ordinary Differential Equations ; Xenopus Laevis; Histone H4; Parameter-estimation; Lysine-20; Chromatin; Methyltransferase; Monomethylation; Trimethylation; Purification; Specificity; Transition
ISSN (print) / ISBN 2405-4712
e-ISSN 2405-4720
Zeitschrift Cell Systems
Quellenangaben Band: 11, Heft: 6, Seiten: 653-662.e8 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Maryland Heights, MO
Nichtpatentliteratur Publikationen
Institut(e) Institute of Computational Biology (ICB)
Förderungen Technical University of Munich's Department of Mathematics
European Research Council (ERC)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
BMBF project TIDY