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Valera, G. ; Markov, D.A.* ; Bijari, K.* ; Randlett, O.* ; Asgharsharghi, A. ; Baudoin, J.P.* ; Ascoli, G.A.* ; Portugues, R.* ; López-Schier, H.

A neuronal blueprint for directional mechanosensation in larval zebrafish.

Curr. Biol. 31, 1463-1475.e6 (2021)
Verlagsversion Postprint Forschungsdaten DOI PMC
Open Access Green
Animals have a remarkable ability to use local cues to orient in space in the absence of a panoramic fixed reference frame. Here we use the mechanosensory lateral line in larval zebrafish to understand rheotaxis, an innate oriented swimming evoked by water currents. We generated a comprehensive light-microscopy cell-resolution projectome of lateralis afferent neurons (LANs) and used clustering techniques for morphological classification. We find surprising structural constancy among LANs. Laser-mediated microlesions indicate that precise topographic mapping of lateral-line receptors is not essential for rheotaxis. Recording neuronal-activity during controlled mechanical stimulation of neuromasts reveals unequal representation of water-flow direction in the hindbrain. We explored potential circuit architectures constrained by anatomical and functional data to suggest a parsimonious model under which the integration of lateralized signals transmitted by direction-selective LANs underlies the encoding of water-flow direction in the brain. These data provide a new framework to understand how animals use local mechanical cues to orient in space.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Hair Cells ; Lateral Line ; Mechanosensation ; Neurons ; Projectome ; Rheotaxis ; Single-cell Tracing ; Somatotopy; Posterior Lateral-line; Afferent Neurons; Hair-cells; Organization; Rheotaxis; Goldfish; Projectome; Synapses; System; Maps
ISSN (print) / ISBN 0960-9822
e-ISSN 1879-0445
Zeitschrift Current Biology
Quellenangaben Band: 31, Heft: 7, Seiten: 1463-1475.e6 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Sensory Biology and Organogenesis (SBO)
Förderungen Helmholtz Association
BMBF
NIH BRAIN Initiative
Max-Planck Society
NIH