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Valera, G. ; Markov, D.A.* ; Bijari, K.* ; Randlett, O.* ; Asgharsharghi, A. ; Baudoin, J.P.* ; Ascoli, G.A.* ; Portugues, R.* ; López-Schier, H.

A neuronal blueprint for directional mechanosensation in larval zebrafish.

Curr. Biol. 31, 1463-1475.e6 (2021)
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Animals have a remarkable ability to use local cues to orient in space in the absence of a panoramic fixed reference frame. Here we use the mechanosensory lateral line in larval zebrafish to understand rheotaxis, an innate oriented swimming evoked by water currents. We generated a comprehensive light-microscopy cell-resolution projectome of lateralis afferent neurons (LANs) and used clustering techniques for morphological classification. We find surprising structural constancy among LANs. Laser-mediated microlesions indicate that precise topographic mapping of lateral-line receptors is not essential for rheotaxis. Recording neuronal-activity during controlled mechanical stimulation of neuromasts reveals unequal representation of water-flow direction in the hindbrain. We explored potential circuit architectures constrained by anatomical and functional data to suggest a parsimonious model under which the integration of lateralized signals transmitted by direction-selective LANs underlies the encoding of water-flow direction in the brain. These data provide a new framework to understand how animals use local mechanical cues to orient in space.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hair Cells ; Lateral Line ; Mechanosensation ; Neurons ; Projectome ; Rheotaxis ; Single-cell Tracing ; Somatotopy; Posterior Lateral-line; Afferent Neurons; Hair-cells; Organization; Rheotaxis; Goldfish; Projectome; Synapses; System; Maps
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0960-9822
e-ISSN 1879-0445
Journal Current Biology
Quellenangaben Volume: 31, Issue: 7, Pages: 1463-1475.e6 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Research Unit Sensory Biology and Organogenesis (SBO)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500100-001
Grants Helmholtz Association
BMBF
NIH BRAIN Initiative
Max-Planck Society
NIH
DOI 10.1016/j.cub.2021.01.045
WOS ID WOS:000640082800010
Scopus ID 85101070628
PubMed ID 33545047
Erfassungsdatum 2021-04-21
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