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Götz, M. ; Bocchi, R.

Neuronal replacement: Concepts, achievements, and call for caution.

Curr. Opin. Neurobiol. 69, 185-192 (2021)
Verlagsversion DOI PMC
Open Access Hybrid
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Regenerative approaches have made such a great progress, now aiming toward replacing the exact neurons lost upon injury or neurodegeneration. Transplantation and direct reprogramming approaches benefit from identification of molecular programs for neuronal subtype specification, allowing engineering of more precise neuronal subtypes. Disentangling subtype diversity from dynamic transcriptional states presents a challenge now. Adequate identity and connectivity is a prerequisite to restore neuronal network function, which is achieved by transplanted neurons generating the correct output and input, depending on the location and injury condition. Direct neuronal reprogramming of local glial cells has also made great progress in achieving high efficiency of conversion, with adequate output connectivity now aiming toward the goal of replacing neurons in a noninvasive approach.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Neuronal Replacement Therapies ; Transplantation And Direct Neuronal Reprogramming; In-vivo; Parkinsons-disease; Functional-neurons; Dopamine Neurons; Progenitor Cells; Ng2 Glia; Neural Stem; Astrocytes; Brain; Conversion
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0959-4388
e-ISSN 1873-6882
Zeitschrift Current Opinion in Neurobiology
Quellenangaben Band: 69, Heft: , Seiten: 185-192 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
Förderungen SyNergy Excellence Cluster
SNF postdoctoral fellowship
ERC grant ChroNeuroRepair
Roger de Spoelberch Foundation
Micronet (Era-Net)
German Research Foundation
DOI 10.1016/j.conb.2021.03.014
WOS ID WOS:000687828000023
Scopus ID 85105460045
PubMed ID 33984604
Erfassungsdatum 2021-06-21
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