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Han, J.* ; Harrison, L. ; Patzelt, L.* ; Wu, M.* ; Junker, D.* ; Herzig, S. ; Berriel Diaz, M. ; Karampinos, D.C.*

Imaging modalities for diagnosis and monitoring of cancer cachexia.

EJNMMI Res. 11:94 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily implicates lean body mass, caused by an aberrant metabolism and systemic inflammation. This may lead to disease aggravation, poorer quality of life, and increased mortality. Timely detection is, therefore, crucial, as is the careful monitoring of cancer progression, in an effort to improve management, facilitate individual treatment and minimize disease complications. A detailed analysis of body composition and tissue changes using imaging modalities-that is, computed tomography, magnetic resonance imaging, (18F) fluoro-2-deoxy-D-glucose (18FDG) PET and dual-energy X-ray absorptiometry-shows great premise for charting the course of cachexia. Quantitative and qualitative changes to adipose tissue, organs, and muscle compartments, particularly of the trunk and extremities, could present important biomarkers for phenotyping cachexia and determining its onset in patients. In this review, we present and compare the imaging techniques that have been used in the setting of cancer cachexia. Their individual limitations, drawbacks in the face of clinical routine care, and relevance in oncology are also discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Adipose Tissue ; Cancer Cachexia Progression ; Computed Tomography (ct) ; Imaging Biomarkers ; Imaging-based Phenotyping ; Magnetic Resonance Imaging (mri) ; Skeletal Muscle; Brown Adipose-tissue; X-ray Absorptiometry; Body-composition; Muscle Mass; Computed-tomography; Clinical-implications; Energy-expenditure; Fat; Sarcopenia; Prevalence
ISSN (print) / ISBN 2191-219X
e-ISSN 2191-219X
Zeitschrift EJNMMI Research
Quellenangaben Band: 11, Heft: 1, Seiten: , Artikelnummer: 94 Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Deutsche Forschungsgemeinschaft