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Paeschke, S.* ; Winter, K.* ; Bechmann, I.* ; Klöting, N. ; Blüher, M. ; Baum, P.* ; Kosacka, J.* ; Nowicki, M.*

Leptin receptor-deficient db/db mice show significant heterogeneity in response to high non-heme iron diet.

Front. Nutr. 8:741249 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Recent studies have shown an association between iron homeostasis, obesity and diabetes. In this work, we investigated the differences in the metabolic status and inflammation in liver, pancreas and visceral adipose tissue of leptin receptor-deficient db/db mice dependent on high iron concentration diet. 3-month-old male BKS-Leprdb/db/JOrlRj (db/db) mice were divided into two groups, which were fed with different diets containing high iron (29 g/kg, n = 57) or standard iron (0.178 g/kg; n = 42) concentrations for 4 months. As anticipated, standard iron-fed db/db mice developed obesity and diabetes. However, high iron-fed mice exhibited a wide heterogeneity. By dividing into two subgroups at the diabetes level, non-diabetic subgroup 1 (<13.5 mmol/l, n = 30) significantly differed from diabetic subgroup two (>13.5 mmol/l, n = 27). Blood glucose concentration, HbA1c value, inflammation markers interleukin six and tumor necrosis factor α and heme oxygenase one in visceral adipose tissue were reduced in subgroup one compared to subgroup two. In contrast, body weight, C-peptide, serum insulin and serum iron concentrations, pancreatic islet and signal ratio as well as cholesterol, LDL and HDL levels were enhanced in subgroup one. While these significant differences require further studies and explanation, our results might also explain the often-contradictory results of the metabolic studies with db/db mice.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Db/db Mice ; Diabetes Mellitus ; Inflammation ; Iron ; Metabolism ; Obesity; Improves Insulin Sensitivity; Adipose-tissue; Epithelial-cells; Genetic-analysis; Carbonyl Iron; Obesity; Glucose; Mouse; Inflammation; Adiponectin
ISSN (print) / ISBN 2296-861X
e-ISSN 2296-861X
Zeitschrift Frontiers in Nutrition
Quellenangaben Band: 8, Heft: , Seiten: , Artikelnummer: 741249 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen Leipzig University
Deutsche Diabetes Gesellschaft