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Chen, Y.* ; Kassam, I.* ; Lau, S.H.* ; Kooner, J.S.* ; Wilson, R. ; Peters, A. ; Winkelmann, J. ; Chow, V.T.* ; Khor, C.C.* ; van Dam, R.M.* ; Teo, Y.Y.* ; Loh, M.* ; Sim, X.*

Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: An EWAS in multi-ethnic Asian individuals.

Clin. Epigenet. 13:195 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in non-Asian populations. Methods: We performed an epigenome-wide association study (EWAS) on general adiposity (body mass index, BMI) and abdominal adiposity (waist circumference, WC) in 409 multi-ethnic Asian individuals and replicated BMI and waist-associated DNA methylation CpGs identified in other populations. The cross-lagged panel model and Mendelian randomization were used to assess the temporal relationship between methylation and BMI. The temporal relationship between the identified CpGs and inflammation and metabolic markers was also examined. Results: EWAS identified 116 DNA methylation CpGs independently associated with BMI and eight independently associated with WC at false discovery rate PFDR < 0.05 in 409 Asian samples. We replicated 110 BMI-associated CpGs previously reported in Europeans and identified six novel BMI-associated CpGs and two novel WC-associated CpGs. We observed high consistency in association direction of effect compared to studies in other populations. Causal relationship analyses indicated that BMI was more likely to be the cause of DNA methylation alteration, rather than the consequence. The causal analyses using BMI-associated methylation risk score also suggested that higher levels of the inflammation marker IL-6 were likely the consequence of methylation change. Conclusion: Our study provides evidence of an association between obesity and DNA methylation in multi-ethnic Asians and suggests that obesity can drive methylation change. The results also suggested possible causal influence that obesity-related methylation changes might have on inflammation and lipoprotein levels.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Body Mass Index ; Dna Methylation ; Epigenome-wide Association Study ; Inflammation ; Metabolites ; Obesity ; Waist Circumference; Body-mass Index; Insulin-resistance; Obesity; Association; Loci; Disease; Profile; Gene; Inflammation; Adiposity
ISSN (print) / ISBN 1868-7075
e-ISSN 1868-7083
Zeitschrift Clinical Epigenetics
Quellenangaben Band: 13, Heft: 1, Seiten: , Artikelnummer: 195 Supplement: ,
Verlag Springer
Verlagsort Berlin : Heidelberg
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Neurogenomics (ING)
Förderungen German Federal Ministry of Education and Research (BMBF)
National University of Singapore (NUS) [Translational Laboratory in Genetic MedicineIntegrative Omics Group (TLGM-iOX)]
Agency for Science, Technology and Research (A*STAR)
National Research Foundation (Bio-medical Research Council)
National Medical Research Council
Biomedical Research Council
Singapore Ministry of Health's National Medical Research Council