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Janzen, A.* ; Kogan, R.V.* ; Meles, S.K.* ; Sittig, E.* ; Renken, R.J.* ; Geibl, F.F.* ; Booij, J.* ; Stormezand, G.* ; Luster, M.* ; Mayer, G.* ; Leenders, K.L.* ; Oertel, W.H.

Rapid eye movement sleep behavior disorder: Abnormal cardiac image and progressive abnormal metabolic brain pattern.

Mov. Disord., DOI: 10.1002/mds.28859 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Background: Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for α-synucleinopathies. Objective: The aim of this study was to determine whether pathological cardiac [123I]meta-iodobenzylguanidine scintigraphy ([123I]MIBG) is associated with progression of [18F]fluorodeoxyglucose-positron emission tomography–based Parkinson's disease (PD)-related brain pattern (PDRP) expression in iRBD. Methods: Seventeen subjects with iRBD underwent [18F]fluorodeoxyglucose-positron emission tomography brain imaging twice ~3.6 years apart. In addition, [123I]MIBG and [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography ([123I]FP-CIT-SPECT) at baseline were performed. Olfactory, cognitive, and motor functions were tested annually. Results: Twelve of 17 subjects had pathological [123I]MIBG. At baseline, 6 of 12 of these expressed the PDRP (suprathreshold PDRP z score). At follow-up, 12 of 17 subjects had suprathreshold PDRP z scores, associated with pathological [123I]MIBG in 92% and with pathological [123I]FP-CIT-SPECT in 75%. Subjects with pathological [123I]MIBG had higher PDRP z score change per year (P = 0.027). Three subjects phenoconverted to PD; all had pathological [123I]MIBG and [123I]FP-CIT-SPECT, suprathreshold baseline PDRP z scores, and hyposmia. Conclusions: Pathological [123I]MIBG was associated with progressive and suprathreshold PDRP z scores at follow-up. Abnormal [123I]MIBG likely identifies iRBD as prodromal PD earlier than pathological [123I]FP-CIT-SPECT. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Hyposmia ; Isolated Rapid Eye Movement Sleep Behavior Disorder ; Prodromal Progression Biomarker ; [ I]mibg Scintigraphy 123 ; [ F]fdg-pet-derived Parkinson's Disease–related Pattern 18; Myocardial Scintigraphy; Olfactory Dysfunction; Parkinsons-disease; Dementia; Synucleinopathy; Biomarkers; Spect; Tool
ISSN (print) / ISBN 0885-3185
e-ISSN 1531-8257
Zeitschrift Movement Disorders
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Neurogenomics (ING)
Förderungen Projekt DEAL
German "ParkinsonFonds Deutschland"
Dutch "Stichting ParkinsonFonds"