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Differentiation of human pluripotent stem cells into pancreatic duct-like organoids.
STAR Protoc. 2:100913 (2021)
The recapitulation of human developmental processes and pathological manifestations requires access to specific cell types and precursor stages during embryogenesis and disease. Here, we describe a scalable in vitro differentiation protocol to guide human pluripotent stem cells stepwise into pancreatic duct-like organoids. The protocol mimics pancreatic duct development and was successfully used to model the onset and progression of pancreatic ductal adenocarcinoma; the approach is suitable for multiple downstream applications. However, the protocol is cost- and time-intensive. For complete details on the use and execution of this protocol, please refer to Breunig et al. (2021).
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cell Culture ; Cell Differentiation ; Developmental Biology ; Organoids ; Stem Cells
e-ISSN
2666-1667
Zeitschrift
STAR Protocols
Quellenangaben
Band: 2,
Heft: 4,
Artikelnummer: 100913
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Helmholtz Pioneer Campus (HPC)
Förderungen
Deutsche Krebshilfe (Germany)
Else Kroner-Forschungskolleg (Else Kroner-Fresenius-Stiftung) of the Technical University of Munich (TUM)
'Deutsche Forschungsgemeinschaft (DFG)'
Else Kroner-Forschungskolleg (Else Kroner-Fresenius-Stiftung) of the Technical University of Munich (TUM)
'Deutsche Forschungsgemeinschaft (DFG)'