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Qi, R.* ; Cao, J.* ; Sun, Y.* ; Li, Y.* ; Huang, Z.* ; Jiang, D. ; Jiang, X.H.* ; Snutch, T.P.* ; Zhang, Y.* ; Tao, J.*

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels.

Proc. Natl. Acad. Sci. U.S.A. 119:e2117209119 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
SignificanceIn this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of the miR-32-5p gene and decreases the expression of miR-32-5p, in turn promoting the development of neuropathic pain through regulation of Cav3.2 channels. miRNA-mediated gene regulation has been proposed as a therapeutic approach in neuropathic pain. Our findings identify miR-32-5p replenishment as a therapeutic strategy for treating chronic neuropathic pain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cav3.2 ; Microrna ; Neuropathic Pain ; T-type Ca2+ Channels ; Trigeminal Ganglion Neurons
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 119, Heft: 14, Seiten: , Artikelnummer: e2117209119 Supplement: ,
Verlag National Academy of Sciences
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
Förderungen Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation)
Research Innovation Program for College Graduates of Jiangsu Province
Science and Technology Bureau of Suzhou
Jiangsu Key Laboratory of Neuropsychiatric Diseases
Priority Academic Program Development of Jiangsu Higher Education Institutions
National Natural Science Foundation of China (NSFC)