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Stefan, N. ; Sippel, K. ; Heni, M. ; Fritsche, A. ; Wagner, R. ; Jakob, C.E.M.* ; Preissl, H. ; von Werder, A.* ; Khodamoradi, Y.* ; Borgmann, S.* ; Ruethrich, M.M.* ; Hanses, F.* ; Haselberger, M.* ; Piepel, C.* ; Hower, M.* ; vom Dahl, J.* ; Wille, K.* ; Roemmele, C.* ; Vehreschild, J.* ; Stecher, M.* ; Solimena, M. ; Roden, M.* ; Schuermann, A.* ; Gallwitz, B.* ; Hrabě de Angelis, M. ; Ludwig, D.S.* ; Schulze, M.B.* ; Jensen, B.E.O.* ; Birkenfeld, A.L.

Obesity and impaired metabolic health increase risk of COVID-19-related mortality in young and middle-aged adults to the level observed in older people: The LEOSS Registry.

Front. Med. 9:875430 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18-55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55-27.3)] as older (56-75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10-18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Obesity ; Diabetes ; Hypertension ; Impaired Metabolic Health ; Mortality ; Covid-19
ISSN (print) / ISBN 2296-858X
e-ISSN 2296-858X
Zeitschrift Frontiers in Medicine
Quellenangaben Band: 9, Heft: , Seiten: , Artikelnummer: 875430 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute for Pancreatic Beta Cell Research (IPI)
Institute of Experimental Genetics (IEG)
Förderungen German Centre for Diabetes Research (DZD)
Willy Robert Pitzer Foundation
German Centre for Infection Research (DZIF)