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Camargo Ortega, G.* ; Götz, M.

Centrosome heterogeneity in stem cells regulates cell diversity.

Trends Cell Biol. 32, 707-719 (2022)
Postprint DOI PMC
Open Access Green
Stem cells are at the source of creating cellular diversity. Multiple mechanisms, including basic cell biological processes, regulate their fate. The centrosome is at the core of many stem cell functions and recent work highlights the association of distinct proteins at the centrosome in stem cell differentiation. As showcased by a novel centrosome protein regulating neural stem cell differentiation, it is timely to review the heterogeneity of the centrosome at protein and RNA levels and how this impacts their function in stem and progenitor cells. Together with evidence for heterogeneity of other organelles so far considered as similar between cells, we call for exploring the cell type-specific composition of organelles as a way to expand protein function in development with relevance to regenerative medicine.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Centrosome ; Differentiation ; Microtubule Organization ; Migration ; Neurogenesis ; Organelle Heterogeneity
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Zeitschrift Trends in Cell Biology
Quellenangaben Band: 32, Heft: 8, Seiten: 707-719 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)