PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Heydarian, M. ; Schulz, C.* ; Stöger, T. ; Hilgendorff, A.

Association of immune cell recruitment and BPD development.

Mol. Cell. Pediatr. 9:16 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focus of many studies has been the characteristic inflammatory responses provoked by these exposures. Here, we review the relationship between immaturity and prenatal conditions, as well as postnatal exposure to mechanical ventilation and oxygen toxicity, with the imbalance of pro- and anti-inflammatory regulatory networks. In these conditions, cytokine release, protease activity, and sustained presence of innate immune cells in the lung result in pathologic processes contributing to lung injury. We highlight the recruitment and function of myeloid innate immune cells, in particular, neutrophils and monocyte/macrophages in the BPD lung in human patients and animal models. We also discuss dissimilarities between the infant and adult immune system as a basis for the development of novel therapeutic strategies.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Altmetric
0.000
0.000
6
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Bronchopulmonary Dysplasia ; Chronic Lung Disease ; Inflammation ; Lung ; Macrophage ; Monocyte ; Neonate ; Neutrophil; Bronchopulmonary Dysplasia; Mechanical Ventilation; Endothelial-cells; Pulmonary Inflammation; Alveolar Macrophages; Lung Inflammation; Fetal Monocytes; Blood Monocytes; Cytokine Levels; Tnf-alpha
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 2194-7791
Zeitschrift Molecular and Cellular Pediatrics
Quellenangaben Band: 9, Heft: 1, Seiten: , Artikelnummer: 16 Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Lung Research
PSP-Element(e) G-552100-001
G-501800-805
G-505000-001
Förderungen Deutsches Zentrum für Lungenforschung
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
Stiftung AtemWeg
German Science and Research Organization
German Ministry of Education and Health
DOI 10.1186/s40348-022-00148-w
WOS ID 001009633200001
Scopus ID 85135252737
PubMed ID 35917002
Erfassungsdatum 2022-11-07
[➜Korrektur melden]